The structure of amino treated magnetic polystyrene microspheres is typically sandwich type. The inner core is monodisperse polymer microspheres. Magnetic oxide layer is in the middle between uniform polymer microspheres and the outermost layer which is hydrophilic and hydroxyl functionalized polymer layer. By amination, hydroxyl groups convert to amino groups.
Through cross-linking reagents (such as glutaraldehyde, etc.), amino treated magnetic polystyrene microspheres are able to covalently coupled with protein ligands (such as antigen, antibody, etc.), oligonucleotide probes and other biomolecules on the surface,which makes amino treated magnetic polystyrene microspheres an important carrier in medical and molecular biology research.
It can be widely used as below:
- Nucleic acid separation
- Immunoassay, can be functionalized with protein and purify antibody
- Cell separation
- Drug combination and targeted drug delivery
- Detecting biologically active substances
- Sample enrichment and separation