Project Description

Vanco-purification-chromatographyEPRUI Biotech has developed a vancomycin purification chromatography medium which is specially designed for high efficient separation and purification of Vancomycin. EPRUI vanco chromatography media is a spherical and monodisperse microspheres with precisely controlled particle size and optimized pore structure. EPRUI Vanco chromatography media  provides excellent selectivity, high retention capacity, low back pressure, minimal elution volume, and high recovery yield of Vancomycin. In comparison with other vancomycin purification chromatography available in the market, EPRUI Vanco possesses much higher efficiency in removing dechlorovancomycin. EPRUI Vanco media is very stable in almost all aqueous solutions including NaOH (1 M) and HCl (1 M), and organic solvents, such as IPA, DMSO, THF, Methanol, Acetone, Acetonitrile, guanidine hydrochloride (6 M), etc.

Breakthrough Curves for Vancomycin
breakthrough
Chromatography Data for Vancomycin

Resin Sample Loading capacity(mg/ml) Purity Yield
EPRUI Vanco 36.7 ≥95% 81.4%
Competitor H 36.7 ≥95% 43.5%

Features Benefits
Spherical morphology Easy column packing
Highly uniform particle size High selectivity and loading capacity
Optimized pore structure Long lifetime
Good PH Stability Low back pressure
No filter impurities Consistent high quality
High rigidity High purity
Large scale production capacity


Matrix Spherical monodisperse porous PS/DVB
Particle Size 40um
Coefficient of Variation <3%
Pore Size 300A
Pore Volume ~1.6cm3/g
Surface Area 850m2/g
PH Stability 1-14
Operating Temperature 4-60℃
Max Operating Pressure 40 bar


Item Matrix Particle Size Pore Size CV.
EPRUI Vanco PS/DVB 40um 300A <3%

Dynamic Binding Capacity of EPRUI Vancomycin Purification Chromatography Media
EPRUI Vanco exhibits much higher dynamic binding capacity for Vancomycin and leads to a much higher purity and recovery yield than competitor’s adsorbents as shown below.

Resin 10% Capacity (mg/ml) 100% Capacity(mg/ml)
EPRUI-Vanco 27.5 48
Competitor H 9.6 46